South San Francisco is a city with many parks, pools, and a marina, offering its residents plentiful amenities and fine residential areas. With more than 2,800 firms and businesses, including Genentech, South San Francisco is considered the “Birthplace of Technology.” The historic South San Francisco hillside sign overlooks the city and is visible to drivers on northbound 101 with the words, “SOUTH SAN FRANCISCO THE INDUSTRIAL CITY.” Commonly referred to as “South City,” it is located north of San Bruno and south of Daly City.

In 2022, the South San Francisco average price for a single-family home was $1,383,465, a 6% increase from the previous year.